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#Inmr registration trial
19 In short, MR CLEAN was a randomized clinical trial of EVT with usual care (intervention group) versus usual care alone (control group) in patients (n=500) with a proximal intracranial arterial occlusion in the anterior circulation demonstrated on vessel imaging, treatable within 6 hours after symptom onset. Patient selection criteria and methods of the MR CLEAN trial have been reported previously. We used data from the MR CLEAN and the MR CLEAN Registry. However, all syntax files and output of statistical analyses will be made available upon reasonable request. Individual patient data of the MR CLEAN Registry cannot be made available under Dutch law, as we did not obtain patient approval for sharing individual patient data, even in coded form.
#Inmr registration archive
The data of the MR CLEAN trial (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) have been made publicly available at the Virtual International Stroke Trials Archive and can be accessed at.
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In this study, we aim to identify clinical and imaging determinants that are associated with collateral status on baseline computed tomography angiography in patients with acute ischemic stroke due to a proximal intracranial occlusion in the anterior circulation. Possibly, this might help to find ways to improve collateral status during acute ischemic stroke and thus increase chances of a better clinical outcome. 13–18 Further research on potential determinants for poor collateral status could improve our understanding of the collateral system. 12 Previous studies demonstrated that higher age, diabetes mellitus, history of hypertension, high systolic blood pressure, location of the occlusion, presence of extracranial internal carotid artery (ICA) stenosis and poor hydration status are related to worse collateral status. Genetic factors have been suggested to be the strongest determinants of collateral strength. Little is known about the biological mechanisms that leads to the variability in filling pattern of leptomeningeal collaterals.
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6–9 As a result, several guidelines already recommend collateral status as a method to select patients for EVT. It has been shown that patients with absent collateral flow benefit less from endovascular treatment (EVT). 1–5 Collateral circulation may prevent the penumbra, at least temporarily, to become infarcted by maintaining a certain level of cerebral blood flow. Poor collateral status has been associated with larger follow-up infarct volumes, increased mortality, and poor functional outcome. Leptomeningeal collateral flow has been considered an important determinant of clinical outcome in patients with acute ischemic stroke. Customer Service and Ordering Information.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).